HTTP/1.1 200 OK Cache-Control: no-cache, private Content-Type: text/html; charset=UTF-8 Date: Sat, 28 Nov 2020 02:50:38 GMT 桃隐动漫社区
Jump to main content
Jump to site search

Themed collection Coronavirus articles - free to access collection

156 items - Showing page 1 of 3
Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

大卫评价说:“这唱的太棒了,无可挑剔,简直完美。”
Usain Bolt was the most searched-for non-UK Olympian.

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

香港没有这样的熔断机制,由中国内地企业股票组成的H股指数(香港恒生中国企业指数(HSCEI))周一下跌不到4%,成交量也只是寻常。人们原本可能以为会更加惨烈。中国内地的散户投资者既可进入内地股市,也可进入香港股市——通过沪港通(Stock Connect)和一个有漏洞的体系——而且,如果你无法卖出你想卖的,你就卖你能卖的。一直最不看好中国经济的H股境外投资者也可能被认为是卖方。然而,尽管沪市周二开盘进一步下跌3%(之后出现反弹),香港的H股却依然保持坚挺。
Investors have noticed Honda’s troubles. The automaker was one of the very few worldwide to avoid deep losses during the global financial crisis. Still, its common shares are down 17.2% over the past year, while the Nikkei 225 Index is up 7.4% and Toyota Motor shares are up 19.5%.

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

现在是时候制订新年旅游计划了!有“背包客圣经”之称的《孤独星球》于近日向寻找地美价廉好去处的人们推荐了2017年性价比最高的旅游胜地清单。让我们一起来看看吧。

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

英国和法国成为欧洲商学院教育的两大来源。在上榜商学院中,近一半要么来自英国(20所),要么来自法国(19所)。从排名、毕业生薪资(法国为5.5万美元,英国为4.9万美元)以及学生数量(法国为9000人,英国为1200人)看,法国在管理硕士课程方面强于英国。然而,从MBA商学院数量(英国上榜商学院为18所,法国为5所)和学生数量(英国为1900人,法国为1300人)来看,英国商学院MBA课程强于法国,尽管在毕业生薪资方面,英国MBA课程(11.5万美元)不敌法国(13.7万美元)。

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

stre力量,ngthen-加强力量
The block chain has such rich potential that there is an initiative underway to create additional “side chains,” though there is controversy around that idea. “We don’t really want to mess with the main block chain right now,” says Adam Ludwin, CEO of Chain, a block chain API that makes it easier to create bitcoin applications. “It works, we don’t want to break it.”
The diplomatic row began when Ankara’s foreign minister was denied entry to the Netherlands on Saturday for a campaign rally in favour of Mr Erdogan’s constitutional reforms. Armed Dutch police also intercepted another Turkish minister, Fatma Betul Sayan Kaya, on her way to the rally in Rotterdam and escorted her back to the German border.
如果你想要一个有屏幕的冰箱,不妨把iPad粘在冰箱上。三星在今夏发布了可以连接Wi-Fi的智能冰箱,来帮助管理杂货和给家庭成员留言。

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

你说的有道理。那我们就把国王队归到“有可能”的那一档里吧。同样我会把掘金队也归到这一档,鉴于他们球队战绩相近,且都或放走或签约了某些功能失调的球员。奇才队也会被我归到这一档,到目前为止我还是不看好他们。
他通过电梯门递出一张纸条,上面写着"有人被困在电梯内,请叫物业来帮忙。"寄希望于有人可以捡到并来救他。
然后,他用那把小提琴砸穿了那幅画。
单词effective 联想记忆:

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

用户在百度搜索平台上最常点阅的新闻事件是,为纪念二战胜利70周年于9月3日在北京举行的阅兵仪式。在此次庆祝活动中,上万名军人接受了现任国家主席习近平、前任主席胡锦涛和江泽民,以及多位外国领导人的检阅,其中包括俄罗斯总统弗拉基米尔·V·普京(Vladimir V. Putin)。

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

我发现自己经常担心一些事情

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

台风艾玛
The Producer Price Index (PPI), which gauges factory-gate prices and is a major indicator of economic briskness, rose by 6.3% in 2017, compared with a minus 1.4% for 2016, reversing the trend of continual decline since 2012.

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

土耳其外交部愤怒地驳斥了欧盟的批评。它说:“欧盟应该意识到,这种声明助长了极端主义,比如仇外和反土耳其情绪,因为它对避免过分言论和行动以免局势进一步恶化的呼吁,针对的只是土耳其,而不是所有违反外交公约和国际法、从而导致了这种局面的国家。”
May everything beautiful and best be condensed into this card. I sincerely wish you happiness, cheerfulness and success.

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

单词haven 联想记忆:
但随着美国接近实现充分就业,随着通胀向目标水平趋近,“你可以看到收紧政策是有道理的,”他说,“不需要很多就足以改变整个平衡”。

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

n. 商业广告
n. 火焰,热情
这其中包括麦肯锡(McKinsey)。去年10月,这家咨询机构的500多名高级合伙人汇聚伦敦格罗夫纳豪斯酒店(Grosvenor House Hotel),启动了神神秘秘的领导层选举程序。下一阶段涉及该公司550名高级合伙人于1月对鲍达民(Dominic Barton)继任者的候选名单进行投票,之后在2月份对两名人气最高的候选人进行第二轮投票。鲍达民自2009年起执掌麦肯锡。
Like any college kid, Evan Wray loved using the tiny pictograms known as emoji. But he hated that there was no emoji to express his Fighting Irish pride with fellow University of Notre Dame students. So, alongside co-founder Sean O’Brien, he built a modest business on that disconnect. TextPride, as it was called, licensed images from brands in the sports and entertainment world and sold them as sticker packs. Within a messaging app like Kik, users could buy a packet of stickers for Disney’s Frozen for $1.99, for example.

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

If you constantly arrive late to work, or return late from breaks, it displays an attitude of complacency and carelessness. So be prompt or even a bit early to show that you are time conscious and that you do care about your job and other people’s time, as well.

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

n. 火焰,热情
The four megalopolises also saw fewer traffic jams after November due to reasons ranging from less travel in winter and smoggy days to the return of migrant workers to their hometowns.

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

根据中国国家统计局的数据,10月份中国规模以上工业增加值同比增长6.1%,与9月份的增幅一致,略低于经济学家的预期中值6.2%。

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

It was billed as the year in which female film-makers and women's issues would be in the spotlight. The festival opened with a film by a female director for the first time in 28 years, Isabella Rossellini chaired the Un Certain Regard jury and Salma Hayek convened a high-profile panel to discuss the role of women in cinema. There was plenty to talk about – but had anything really changed? The numbers seemed to speak for themselves: of the 19 films in competition, only two were directed by women. And then came 'Heelgate' – of which, more later… Faced with suggestions that the festival is sexist, artistic director Thierry Frémaux was having none of it. Cannes was being held to an unfairly high standard, he claimed, one not applied to other festivals like Venice or Berlin. His suggestion? Instead, people should “attack the Oscars”.

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

由于今年是意大利标志性导演米开朗基罗·安东尼奥尼逝世10周年,为向大师致敬,将放映他的13部经典作品--从他的出道作品《某种爱的记录》到1995年的爱情片《云上的日子》。
The other issue with tanking is Philly, Phoenix, and Brooklyn are all bad teams. It's going to be hard to outflank those outfits.
对于那些已把自家公寓改造成B&B旅店的纽约人,围绕非法住宿的论战可能会趋于白热化。而在这一切之上,市长比尔·白思豪(Bill de Blasio)的十年保障性住房计划将初具规模;与此同时,本次奥尔巴尼会议(Albany)的立法将给租房者的钱包造成重负。随着我们迈向新的一年,这类改变游戏规则的因素也正在日益迫近。
除了这些理论之外,还有传统经济学家用来误导美国的坏的统计数据:最恶劣的是GDP,它在衡量美国长期增长的时候是一个狭窄的、误导人的指标。其次,我们对短期数据(每日收盘情况、季度业绩、年度回报等)的执迷正在阻碍美国的长远增长。

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
From the themed collection: 广东住房公积金接入全国数据平台
Review Article

Influenza neuraminidase: A druggable target for natural products

1950年巴西首次承办世界杯,由于要在家照顾卧病在床的母亲,巴西球迷朱蒂尔·桑乔·贝尔蒙特错过了巴西与乌拉圭的决赛。六十四年过后,贝尔蒙特用原版未曾使用的决赛门票换取了三张本届世界杯决赛的入场券。
可口可乐(Coca-Cola)下调了今年的销售预测,该公司正艰难应对中国消费放缓,这导致该饮料集团股价下跌逾3%。
南韩的活动分子在星期二发誓,要在月底通过宣传气球跨越边境向北韩偷运荷里活讽刺片"刺杀金正恩",以作为对北韩不断威胁的反抗。
This is the sixth edition of the QS World University Rankings by Subject, featuring a record-breaking 42 disciplines, making it the largest-ever ranking of the kind. The expert opinion of the world's top 76,798 academics and 44,426 employers informed the results, alongside the analysis of 28.5 million research papers and over 113 million citations sourced from the Scopus/Elsevier bibliometric database, said QS.
The remarks by Recep Tayyip Erdogan come less than 24 hours before Dutch voters go to the polls in a national election that has been coloured by a heated debate about the role of Islam in Dutch society, spurred by anti-Islam candidate Geert Wilders. Mr Wilders’ Freedom party (PVV) is polling second in the race.

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

在以结束迫害科索沃境内阿尔巴尼亚族为目的和平谈判破裂后,北约于1999年3月24日开始了轰炸行动。南斯拉夫和科索沃境内的目标均受到了打击,首先是对抗北约战机的塞尔维亚防空网络,接下来是一系列范围更大的目标,包括被指直接参与迫害科索沃人的南斯拉夫军事力量。目标清单中还包括南斯拉夫首都贝尔格莱德境内的政治和军事目标。
第一次出现在人体内。禽类可能是病毒来源。Appeared for the first time in humans. It caused illness in two children in Hong Kong, with poultry being the probable source.

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
From the themed collection: 2015下半年家居行业新政策大盘点
Critical Review

The role of biosensors in the detection of emerging infectious diseases

Company: Eventbrite

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
From the themed collection: 佛山LED照明产业“颓势”分析
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

n. 宪章,特许,(船、机、车等的)租赁

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

韩国全州——在全州的韩屋村,仍保留着几百座传统的韩式房屋。
The 500 brands come from 28 different countries, among which nearly half, 227, are from the US.
No students or teachers drank the poisoned water, the report said.
Talented getaway driver Baby (Ansel Elgort) relies on the beat of his personal soundtrack to be the best in the game. After meeting the woman (Lily James) of his dreams, he sees a chance to ditch his shady lifestyle and make a clean break. Coerced into working for a crime boss (Kevin Spacey), Baby must face the music as a doomed heist threatens his life, love and freedom.

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

“When I started in this business, Brooklyn was the alternative. Now it is a choice,” said Diane M. Ramirez, the chief executive of Halstead Property. “I see Queens becoming that way. The Bronx is not that far down the line.”
The story of the strong V-shaped recovery of the Chinese economy this year was followed by reports of soaring housing prices in many cities.
Are you ready for a summer scare? Conjuring 2: The Enfield Poltergeist is set to hit the screens on June 10, 2016. We reckon that this is going to be a good horror movie.
金发女郎乐队《花粉传播者》

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

Life Is Strange
This year, online storefronts will generate an estimated $294 billion, or approximately 9% of all U.S. retail sales, according to forecasts by Forrester Research. By 2018, e-commerce will account for more than 11% of the total, or approximately $414 billion, with transactions made with tablets and smartphones accounting for about 20% of the online total, Forrester projects.

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
From the themed collection: 天津爆炸:美克等家居企业受损
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

2. Livers grow by almost half during waking hours. New research suggests that livers have the capacity to grow by almost 50 percent during the day, before shrinking back to their original size at night. They are the only organ we know of that oscillate this way.
Format: Alternating Friday-Saturday classes, with an initial week-long meeting and a week-long international study seminar
The ECB ended the year with a vote on December 3 to cut its deposit rate to minus 0.3 per cent and an expansion in asset purchases that leaves its quantitative easing programme at 1.46tn. The move came days before the US Federal Reserve increased interest rates for the first time since 2006, underlining the sharply divergent policies being pursued on either side of the Atlantic.
con全部+fid相信+ent表示形容词,“…的”→自信的
Bursts of color are instant energy suppliers. If you can, paint your walls or use furniture and accessories to provide a colorful oomph.

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

“One person had his wife call to tell his boss he was not coming back.”
而在科隆游戏展上正式宣布的特色作品中,《寂静岭》(Silent Hills)的最新续集赫然在列。这是科乐美(Konami)最为畅销的恐怖题材游戏(还据此改编成了两部电影)。世界级游戏和电影专家,《合金装备5:幻痛》(Metal Gear Solid V: The Phantom Pain)的制作者小岛秀夫,以及《环太平洋》(Pacific Rim)的导演吉尔莫o德尔o托罗在这部游戏中强强联手。曾出演美剧《行尸走肉》(The Walking Dead)的影星诺曼o瑞杜斯将在游戏中担纲主角。
Video footage recorded by the RSPCA shows the house littered with mess, including animal faeces.

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

如果你觉得现在的杜兰特骨瘦如柴,那你得瞧瞧他在蒙特罗斯基督教会学校时的瘦弱身板。
我的预感是到了3月份,今年的应考新秀们就会看起来很棒,并且会远比去年要好,去年是近几年来最不被看好的一年。新奥尔良和华盛顿都需要一个明确的方向,并且他们不久就会做出各自的选择。

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

Haruhiko Kuroday, the Japanese central bank governor said: “I think we can be cautiously optimistic about the global outlook.
'Inside Llewyn Davis' finds the Coen brothers, Joel and Ethan, in a hauntingly somber mood that somehow translates into memorable drama. I think my review should have made it clearer that this elegy for a casualty of pop culture is a special taste; some of it is fairly glum. So much of it, though, gets to something stirring by way of Oscar Isaac's phenomenal performance as a self-defeating folk singer fatefully dedicated to his art.
财新经济学家何帆表示:“这表明宏观经济已进一步趋稳,经济结构正在改善。今后必须协调财政政策和货币政策,尽可能避免大规模刺激。”

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

一位新浪微博网友写道:“不敢相信这么多医生都在论文中造假。病人还能相信他们可以帮人治病吗?”
Amid rising pollution and a strengthening yuan, the capital city saw its tourist numbers drop to 4.20 million visits from January to November from 5.01 million visits in 2012, according to China Daily, citing a report from China Tourism Academy and Beijing Commission of Tourism Development. An earlier report based on a survey of domestic travel agents showed that visitors to the capital declined by roughly 50% in the first three-quarters of the year compared with a year earlier.
pre前,de,cess走,or人:在前面走的人-前辈

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
From the themed collection: 多家房企完成全年销售目标
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

节目11 歌曲《我心永恒》,席琳-迪翁

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

我们坐在这里指点江山,告诉那些球队“你们没指望了,赶紧输球摆烂吧!”这是很容易的,但是我们并不是那些在为球队门票和广告殚精竭虑的家伙们。

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

7. Viceroy's House
TextPride已经改名为Swyft Media,并推出了一个能将新品牌表情符号和贴纸推送到短信应用中的新平台。各大品牌需要为此付费,一如传统的广告推广活动。

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

这位官员表示,相比其他职位来说,那些对教育背景或工作经历没有特殊要求的职位更受欢迎,近些年报名人数达到数千人的基本上都是这种职位。
从周日起,各地的观众都在叹息该剧剧终,至少从Twitter名人的帖子来看是这样的。
*剧情类最佳客串女演员:玛格?马丁戴尔(Margo Martindale),《美国谍梦》(The Americans)
If we ask "What salary are you looking for?" say you're flexible, or say it depends on the responsibilities of the job. Try not to name a salary unless we really push you, because that gives us a leg up in the negotiating.

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

Recruits are expected to have a decent degree result — a 2.1 or above. While academic credentials are important, Teach First also looks for personal skills such as humility, respect and empathy. Applications to join the scheme outnumber the places available by seven to one.
Mr. Murray came to her with a full beard, so she was able to shape it into the thick, bushy mustache pictured here. “Bill has never worn that look before,” Ms. Hannon said, “so it was lovely to get something new.”

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
From the themed collection: 违建挡光 维权近十年没解决
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

201001/94005.shtml【英文原文】
从校友达到目标的程度来说,伦敦商学院课程的排名一直领先。一位2010届MBA毕业生在回应英国《金融时报》的调查时表示:“凭借我找到的工作,我不仅实现了自己设定的目标,还超出了这些目标。”

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

After years working with large consumer product companies like Stride Rite and Keds, Pieri grew frustrated with the difficulty mom-and-pop shops had launching new products. "The more innovative a product—as opposed to mainstream and "known"—the harder it was to get distribution," she explains. In response, she launched The Grommet, a discovery platform that connects customers with inventors' stories and their products, five years ago. Pieri, whose company helped launch products including SodaStream and Fitbit, counts HP CEO Meg Whitman as a mentor and has a side-gig as an entrepreneur in residence at Harvard Business School.

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

To make a long story short, the Seppenwolde group went bankrupt shortly after Christmas of 1772. The disaster was a top story in Dutch newspapers. It ruined some of Amsterdam’s merchants and bankers. To prevent a general credit collapse, the city of Amsterdam stepped in temporarily as a lender of last resort. Sound familiar?
是的,这经常发生。你可以在家里,图书馆,打印店等除了你现在工作的公司办公室的任何地方打印申请材料。
South Africa's leader Jacob Zuma got a 4% raise in March, but his salary in dollar terms has actually dropped compared to last year, because of the fall in the south African rand.
尽管必须找到方法整合公民的观点,但始终会有缺陷。

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

As the first of its kind, these monkey stamps are sought-after items, with a single stamp fetching 12,000 yuan, much more than its original face value of 0.8 yuan. The complete set of stamps is priced at 1.5 million yuan.
新年可能平淡开场。但在中国不是这样,2016年中国股市的开局相当刺激,交易员们简直要窒息在泡沫中:周一沪市下跌7%,深市跌幅超过了8%。情况本来可能会更糟糕。一项在沪深300指数下跌7%时暂停交易的新机制让这场大戏提早落幕——就这次的情况而言,是提早了一个半小时。

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

Most popular vehicle
罗宾哈丁(Robin Harding)
adj. 受影响的,受感动的,受疾病侵袭的 adj. 做

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

[pr?'d?ektid]
特斯拉是一款富人车。在均价85,000美元的水平线上,可以说买特斯拉的人没人会在意汽油钱。特斯拉在续航里程上的短板,也说明了它绝对不会是车主家里的唯一一辆车。如果这些人的新鲜劲儿过去了,特斯拉的订单储备就会缩水,也会像其它厂商一样需要为销量打拼。
然而,克普克认为,美国利率在引发新兴市场危机方面的作用未被充分认识。他提供的证据表明,如果以下三种情况同时出现的话——处于美联储紧缩周期,联邦基金利率高于自然利率(导致实际产出趋近潜在产出的利率),以及美联储将比先前预期更快收紧政策的信号让市场参与者感到惊讶——新兴市场爆发危机的几率会大大增加。

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

Yet institutions matter, too, because they set the rules of the game.
两者都宣称代表反对外国人和卖国贼的人民。

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
From the themed collection: 智能家居变革“从手控到声控”
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

Zhou Qunfei from Lens Technology, the major touchscreen maker, ranks third on the list with a net worth of 45 billion yuan.
Matt Damon was named best actor in a comedy or musical motion picture for his role as a stranded astronaut in The Martian.
Klay Thompson added 19 points and Andrew Bogut scored 13 for the Warriors, off to the best start by an NBA team since Dallas won its first 14 games in 2002-03. Golden State needs three wins to equal the league record of 15-0, held by the 1948-49 Washington Capitols and 1993-94 Houston Rockets.

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

南韩的活动分子在星期二发誓,要在月底通过宣传气球跨越边境向北韩偷运荷里活讽刺片"刺杀金正恩",以作为对北韩不断威胁的反抗。
在上周二晚上放学后,孙轶潇乘坐电梯回家,可是电梯突然故障停止运行。

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
From the themed collection: 智能家居或成家居产业发展新趋势
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

The continued, albeit slower growth in prices tracks with recent data showing real estate investment ticked upward in October and sales had registered barely any negative impact from the new restrictions.
China's movie box office revenue grew 9 percent to $8.9 billion (RMB 60.98 billion) in 2018.
However, in season two Friends took a big leap toward equality by featuring a gay wedding when Carol married her girlfriend Susan. Behind the scenes, executive producer Marta Kauffman said, "NBC expected thousands and thousands of phone calls and hate mail." However, after the episode aired, they received only four antagonistic letters. As it turns out, people just didn't care that much.

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

超级大坏蛋们将受命保护人类——这就是《自杀小队》的主旨。 一个名叫“A.R.G.U.S”的政府机构招募了一些罪犯帮它执行危险任务,罪犯们将得到的报酬是减刑。这支特遣小队的成员有小丑、死亡射手、哈利·奎恩、回旋镖队长、杀人鳄以及DC漫画宇宙里的其他坏家伙。

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

学会控制自己的情绪,控制自己的想法,克服对被拒绝的恐惧,学会向别人敞开心扉。
“Someone left for lunch and never came back.”

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
From the themed collection: 警惕地板企业环保产品不环保
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

Given that every single Wall Street economist had called for higher rates at the start of this year and 67 of 67 economists surveyed by Bloomberg concurred, the rate-sensitive utilities industry would have been the last sector a rational person would want to overweight. Bets on the financial sector were slow to pay off while wagers on “cheap” energy stocks demolished portfolio performance in the third and fourth quarters, just as they had elevated it during the first and second.
Men and women rated the strengths of their programme equally.

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

Format: Five residential periods with online learning in between
谎言1:不是我!说谎原因:有些事情不值得我们去邀功。

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

5、毕福剑违纪
“What Happened, Miss Simone?” (Liz Garbus)

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

reservation

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

西蒙接受本刊采访时说:“聘用老兵是我们做出的最好的决定之一。我们在阵亡将士纪念日推出了‘欢迎回家’计划,至今我们已经聘用了超过2.6万名老兵,让我们倍感骄傲。老兵在面对压力时表现一贯优秀,而且有服务热情,这些因素让我们很容易兑现聘用老兵、学习老兵和支持老兵的承诺。”
对于很多西方白人来说,取得“获得性身份认同”(登上山巅)的机会似乎已经变得遥不可及。所以“先赋性身份认同”——也就是他们的“白”——变得比以往更加重要起来。
女学员开始攻读EMBA课程的年龄(36岁)较男性年轻两岁左右,但高级职位上的男女比例基本平衡,担任较初级职位的女性略多一些——26%的女学员担任专业职位,男学员的这一比例为24%。
Talking about wanting to kill your boss may not be that uncommon, but it does put a damper on things when said boss actually ends up murdered. When the police came to ask questions, they ended up learning that the Cranston brothers had recently resigned to ride their motorcycles cross-country. Until they could be cleared, the two men were both suspects.

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

根据周一发布的年度调查报告,如今实现澳大利亚梦的成本急剧上升,悉尼和墨尔本超过大多数欧美城市,跻身世界最贵城市前五名。

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

Bringing harmony to Apple’s internal fiefdoms has not been easy. There is still “huge tension” inside Apple, according to one person who has worked with the company for many years. “That tension is something he uses to run the company but it can be dangerous.”
4. Slacking at school
就业市场面临着挑战。约有500万美国人失业已有六个月之久,技能退化令他们未来更难找到工作的风险也加大。此外,收入增长放缓引发的担忧可能会限制企业招聘。据咨询公司CEB今年10月进行的一项调查显示,约有36%的美国高管预计其公司的职员人数会减少;相比之下,今年夏天这一比例为29%。[qh]

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

Tom Hanks has got a slightly more level head around his. He apparently keeps his best actor awards, one each for Philadelphia and Forrest Gump, on the family trophy shelf alongside football (the English kind) trophies and a World’s Greatest Mom trophy left from a mother’s day past.
想要改善自己的生活,而不只是学业,最好的方法之一就是冥想。每天花上十五分钟,静下心来,集中注意力并充满自信。

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
From the themed collection: 家具行业低迷现状或持续到2017年
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

Best Companies rank: 11
2018年特里萨梅(Theresa May)会继续担任英国首相吗

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

Sarah O’Connor is employment correspondent

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

Spielman was sifting through dirt at the Emek Tzurim national park on the slopes of the Mount of Olives in Jerusalem when she noticed the small rectangular object.
1. "Game of Thrones" (5.9 million)
n. 粉底霜,基

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

不会。这笔被誉为史上最大规模的首次公开发行(IPO),是沙特实际领导人穆罕默德本萨勒曼(Mohammed bin Salman)宏大经济重组计划的基石,因此沙特阿美IPO肯定会成行。该公司的股票将在沙特本国的证交所上市。不过,此次IPO计划在国外的部分不太可能是一次公开发行。唐纳德特朗普正在为纽约游说,伦敦也在全力以赴争取。香港和东京也在沙特的考虑之中。但沙特会转而选择非公开售股,或者在晚于预期的时间在国外上市。
According to BusinessInsider.com, 'embracing hyperbole, ' Faber 'suggested that QE would basically be a part of everyday life for the rest of our lives, ' adding that back in 2010 in the early days of Bernanke's disastrous experiment, Faber warned 'the Fed's headed for QE99.'
9.千万别相信民调
4. Add Color

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

美国全国地产经纪商协会(National Association of Realtors)的数据显示,自去年7月份以来美国成屋销量每月都在下滑。这和美国借贷成本上升是同步的。由于美联储暗示将缩减购债计划的规模,整个经济的借贷成本不断上升。
It had hit a record low of 48 in September, and was 49.9 in October.

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

城镇新增就业1100万人以上,城镇登记失业率4.5%以内;
The announcement comes from the British Fashion Council (BFC), who surveyed designers ahead of the shows and found none of the 80 designers in the September line-up would be using fur.
demo人民+-ic…的]→人口统计的

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
156 items - Showing page 1 of 3

About this collection

《大汉情缘之云中歌》
久而久之,这种民族融合给球队带了不同寻常的和谐。队中的年轻球员,尤其是切尔西的阿扎尔和卢卡库以及曼联的贾努扎伊,成了许多竞争对手羡慕的对象。

Spotlight

Advertisements