Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
The online notice about the retraction lists all 107 articles and 524 authors, nearly all of whom are clinical cancer specialists from China. The hospitals named are all top public institutions.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Managers are able to reward their subordinates in unique, personalized ways thanks to the budget they receive from corporate. Two examples of past bonuses: free trail rides at an equestrian stadium and a barbeque with lassoing and horseshow throwing lessons.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
The .40-calibre Smith & Wesson that killed her, a semi-automatic handgun, was seized by police to undergo ballistics testing to determine if it had been used in other crimes.
Volatility in currency markets is also likely to be a factor for agricultural commodity prices in the next 12 months, with the euro likely to depreciate as a result of French, Dutch and German elections, Rabobank reckons.
Trends and targets in antiviral phototherapy
“我去的每一个地方，都发现企业主对未来的需求量有一个很好的预期，” Gus Faucher PNC金融服务机构的资深经济学家称。“商人必须提高薪酬来吸引更多的劳动力或者保留原有的工人”。
这是伦敦商学院(London Business School)和哥伦比亚商学院(Columbia Business School)合办的EMBA-Global项目首次跌出前5名。
? Heavy snow has fallen in West Virginia, with up to 17 inches in Webster Springs. The National Weather Service has warned that more is on the way.
Promote steady development of agriculture and continued increases in rural incomes
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
"Everywhere I go business owners are seeing an increase in demand," said Gus Faucher, senior economist at PNC Financial Services. "Businesses will have to raise wages to attract or maintain workers."
Novel biosensing methodologies for ultrasensitive detection of viruses
My hunch is that this draft will look pretty good by March and will be much better than last year's, which was one of the most underwhelming in recent memory. New Orleans and Washington both need some direction, and soon.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
ACE2 as a potential therapeutic target for pandemic COVID-19
Overall, starting a company ranked lowest among reasons cited for undertaking an EMBA (rated 5.5 out 10). Students’ main motivations were learning about management (9.1), networking (8.3) and increasing earnings (8.1).
Diagnostic technologies for COVID-19: a review
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
时报影评人曼诺拉·达吉斯(Manohla Dargis)与A·O·斯科特(A. O. Scott)分享他们挑选的年度最佳电影。
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Men and women rated the strengths of their programme equally.
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
The Magic have bounced between average and bad, and they're currently on a downswing. Now Aaron Gordon and Nikola Vucevic are coming off the bench and Mario Hezonja is buried.
Siemens broke records last year by winning two awards for renaming its healthcare business Healthineers. Not only does it land the Martin Lukes prize for the worst combination of two words, the accompanying video, featuring a singing CEO and writhing spandex-clad employees, wins a gold medal for most embarrassing company song of all time.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
The tightening drove some enterprises seek other financing options such as bonds or listing on the National Equities Exchange and Quotations (NEEQ).
Influenza neuraminidase: A druggable target for natural products
由美国演员Jared Leto领衔的“火星三十秒”拿到了最佳另类音乐奖，同时还有Lana Del Rey，Lorde，The XX和Imanine Dragons等人提名。
Below are 10 clues you left that basically scream: "I am job searching!"
伦敦商学院(London Business School，见上图)荣登2014年英国《金融时报》欧洲商学院排行榜榜首，该学院上一次夺得冠军宝座是在2005年。法国巴黎高等商学院(HEC Paris)和西班牙企业商学院(IE Business School)分列二、三位。
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
The American share in the total drugspending is about one third. IMS experts estimate that in 2014 it will rise11.7 percent. The UShas particularly high prices, according to the report, but drug makers defendthis by citing the soaring cost of new medicine development.
The role of biosensors in the detection of emerging infectious diseases
《一记耳光》(The Slap)，NBC，2月12日播出。乔恩·罗宾·贝茨(Jon Robin Baitz)与丽莎·查罗登科(Lisa Cholodenko)担任制作人，这部剧改编自一部澳大利亚迷你剧，讲述一个后院生日派对失控后带来的后果。演员阵容非常强大，包括彼得·萨斯加德(Peter Sarsgaard)、乌玛·瑟曼(Uma Thurman)、桑迪·牛顿(Thandie Newton)、布莱恩·考克斯(Brian Cox)和梅丽莎·乔治（Melissa George，她也在原剧中出演角色）。
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
这台叫做IP-BOX的设备可以破解运行iOS 7或者更老版本的iPhone，通常它需要6秒到17小时来破解iPhone的四位锁屏密码。英国《每日邮报》购买了这台设备，并在6小时内破解了苹果iPhone 5c的锁屏密码。该密码破解设备运行在iOS 9系统上的版本将会在本月晚些时候出现。
“不能再采取某些国家先行动，其他国家随后行动的策略，因为时间不多了，”奥斯陆国际气候与环境研究中心(Center for International Climate and Environmental Research)的科学家格伦·P·彼得斯(Glen P. Peters)说。他也参与了这些新数据的编制。“现在需要大家齐心协力。”
But a quick look at the changing skyline betrays a frustrating reality: Those shiny new towers have failed to deliver the type of housing most New Yorkers can afford. “There is a disconnect between what we’re building and what we need to build,” said Jonathan J. Miller, the president of the appraisal firm Miller Samuel. “2015 is going to be more of that.”
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
The area is close to the city centre and the demolition contractors had to make sure that when they brought down the buildings they did not damage a light rail viaduct nearby or a shopping mall and electricity sub-station.
Warm hearted wishes for a happy New Year filled with all your favorite things.传统佳节之际，献上殷殷祝福，祝新年万事如意！
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
The findings of the US and UK scientists are based on thousands of global temperature measurements taken daily on land and at sea.
McGowan has also hit out at Meryl Streep, saying that it is 'literally impossible' the actress knew nothing of Weinstein's sexual proclivities until last autumn.
Inhibition of SARS coronavirus helicase by bismuth complexes
8. It’s never too late to start.
7. Pumping Iron Could Enhance Long-Term Memory
"She gave her surname as Han when registering, which is also different from the name Su in media reports," the employee said.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
7.You Haven't Gotten a Raise in the Last Two Years
“From one son of the South and sports fanatic to another, my hat’s off to you,” tweeted Bill Clinton, the former US president, in response to the article.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
The report didn't comment on potential factors influencing the numbers, but many – including members of the opposing political party – are laying the blame squarely at the feet of government cost-cutting.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
The school ranks first for alumni satisfaction.
"The online Internet anti-corruption bid mostly relies on text, photos and videos and it is easy to be superficial if corrupt officials are only exposed this way."
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Why? Just add in the intensifying anger after the Supreme Court's decisions over same-sex marriage issues and gays, add in the growing anger over abortions, Obamacare, gun control, food stamps, the new voter suppression pushed by GOP governors, plus more threats by conservatives and the tea party to dig in their heels and fight to overturn everything and increase austerity too.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Local-level work experience will advantageous for applicants, with personnel with more than two years of experience at this level given some advantage.
这是两部后自语核(post-mumblecore)喜剧，讲述自我认知及其边界的故事。布西内斯克的影片是完美的怪人三角，三条边分别是盖·皮尔斯(Guy Pearce)、寇碧·史莫德斯(Cobie Smulders)和凯文·科利根(Kevin Corrigan)，以德克萨斯州奥斯汀怪人们轻松胡混的伪装出现。皮文的影片探索精神病以及日间电视节目的的黑暗疆域。由于克里斯汀·韦格(Kristen Wiig)的精彩演出（她饰演一个名叫爱丽丝·克里格的彩票得主），《欢迎来到我的世界》成了关于美国梦想者的精彩肖像，既令人不安，也鼓舞人心。
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Social networking platforms, including Weibo and mobile app WeChat, proved to be the best tools for cyberstars to magnify the power of communication, making it possible to create an industry that combines advertisements, e-commerce and fans.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Rouslan Krechetnikov和Hans Mayer对液体的溅出现象进行了研究。他们考察的课题是：人们在端着咖啡杯走动时咖啡的溅出情况，给你个提示吧，在你走到第七步至第十步之间，咖啡最容易溅出。
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Until now Thor has been the neglected child of the Marvel Cinematic Universe. Though some liked Kenneth Branagh’s first film featuring the god of thunder, Chris Hemsworth was arguably overshadowed by Tom Hiddleston’s preening popinjay of a villain, Loki. And the second film, the humourless Thor: The Dark World, is widely regarded as the worst film released by Marvel Studios to date. So to inject new life into this sagging franchise, Marvel brought in New Zealand comedy auteur Taiki Waititi to add some Kiwi quirk. This time Thor faces down the goddess of death, played by Cate Blanchett. Thor may have the hammer, but she has the attitude. Released November 1 in Serbia and Hungary, November 2 in Cambodia and Israel and November 3 in India and Canada. (Credit: Marvel Studios)
The city of 21 million people recorded 1.86 trillion yuan in total consumption in 2015, marking a yearly rise of 8.7 percent. Consumption contributed over 70 percent to the city's GDP growth.
Madison Marriage is accounting and tax correspondent
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Hope you enjoy the happiness of New Year and all the trimmings.
More than 430,000 students from 1,767 universities in 31 provinces, municipalities and autonomous regions across China were surveyed. Of the respondents, 89.2% had considered starting a business, with 18.2% reporting firm intentions to do so.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
TextPride was a fine business, but a tiny one. Meanwhile, the market for messaging apps was exploding. Facebook FB 0.61% bought WhatsApp for $19 billion; that service now has 700 million monthly active users. Tango, an app with 250 million registered users, is worth $1.5 billion. Kik has 200 million registered users. Snapchat, worth $10 billion, has 100 million users. A new study, commissioned by Kik, shows that U.S. users now spend more time on average in messaging apps than they do on social networking apps. The only problem? These messaging apps need ways to make money, and there’s no reasonable way for advertisers to wedge themselves into conversations between friends.
9. Add Personality
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Global pharmaceutical spending will surpassthe trillion dollar threshold in 2014, with high prices for innovativehepatitis C and cancer drugs in the US, a new study says. By 2018spending is expected to increase by another 30 percent.
According to the Hurun Report’s annual China Rich List, Yao Zhenhua’s net worth surged more than nine times to $17.2bn last year, making him the country’s fourth richest person. Last year he was ranked 204th.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
A 19-year-old girl, referred to as Guo Lingling (this may be a pseudonym), was allegedly struck and kicked repeatedly by her so-called instructors after failing to ask permission to go to the bathroom. An autopsy report showed she died from skull injuries and brain damage.
Best chances: A best film nomination looks certain. Darkest Hour's Gary Oldman is the favorite for best actor, but if anyone can beat him it's probably Chalamet.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
A modular microarray imaging system for highly specific COVID-19 antibody testing
Lopez Short is the name of the game, judging from the red carpet looks of Beyoncé and Jennifer Lopez. Both divas went for thigh-high dresses to show off their gams4, with strategically cut out neck and shoulder detail, but where Beyoncé opted to stand out in fire engine red, J. Lo went for soft and satiny earth tones.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
1.《刺客聂隐娘》(The Assassin)与《疯狂的麦克斯4：狂暴之路》(Mad Max: Fury Road)，并列。侯孝贤和乔治·米勒(George Miller)导演了今年最好的两部商业片，二者都应该到你能找到的最大的屏幕上去看。
Staff numbers at insurance agencies also rose by 936,200 to a total of more than 5.6m people.
When you need help, reach out to people in your networks – that’s what they’re there for. Whether you need a confidence-boosting pep talk or advice about building your technical experience — your mentor, your colleagues, and your manager can help. You may not know how to do something today, but chances are you’re smart enough to find someone who can help you learn it. And once you do, don’t unfasten your seatbelt – there’s always going to be another challenge headed your way.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Jack Ma, founder and executive chairman of e-commerce giant Alibaba Group topped the ranking of China's richest IT people for the third consecutive year.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Among the 772 movies made in China in 2016, 43 of them reached a box office of over 100 million yuan. Chinese movies harvested an overseas box office of 3.8 billion yuan in 2016 with a yearly increase of over 38%.
A facile assay for rapid detection of COVID-19 antibodies
But the economic picture has brightened considerably in Arizona, as the housing market stabilized and unemployment hit a post-recession low of 7.8% in May. As part of Forbes’ annual Best States for Business, we look at 35 factors to determine the best and worst states, including projected employment. Arizona is expected to have the fastest job growth at 3% annually over the next five years, according to Moody’s Analytics. The job gains are projected to boost household incomes 3.6% annually through 2017, which ranks second best in the U.S. after Illinois. The added jobs also go hand-in-hand with the state’s economic growth, which Moody’s forecasts to expand at a U.S.-best 4.6% annually.
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
We learned that we could see a source of ripples in space-time.
President Obama's Cabinet, of which Clinton was once a member, currently comprises seven women and 16 men.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Among dozens of small, technology-focused acquisitions, the $3bn purchase of Beats Electronics, the celebrity-endorsed headphones and music streaming service, stands out as Apple’s largest ever deal. The acquisition still bemuses many Apple analysts, but in Jimmy Iovine and Dr Dre, Beats’ founders, Mr Cook has instantly regained credibility with the music industry after years of neglecting the iTunes download store. If Mr Cook is guilty of missing the rapid growth of subscription services such as Spotify, he has moved swiftly to compensate for it — though for a high price.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Although the average punctuality rate of the surveyed airports rose 7% year-on-year to 70.4% in 2016, the average delay time was 33 minutes.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
A New York City restaurant is taking a stab at creating the most decadent pizza on the market with a pie topped in gold flakes, foie gras and even truffles.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
That figure is more than two times the city's population of about 10 million.
Anti-HIV drug repurposing against SARS-CoV-2
Length-scale dependence of protein hydration-shell density
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
Stand: Starbucks CEO Howard Schultz urged the end of government shutdown
About this collection
201109/155435.shtmlIn August, Jose Javier - from the city of Torrevieja - created an account with AdWords, a Google pay-per-click service.