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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

8.《没问题先生》
The online notice about the retraction lists all 107 articles and 524 authors, nearly all of whom are clinical cancer specialists from China. The hospitals named are all top public institutions.

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

财新经济学家何帆表示:“这表明宏观经济已进一步趋稳,经济结构正在改善。今后必须协调财政政策和货币政策,尽可能避免大规模刺激。”
Managers are able to reward their subordinates in unique, personalized ways thanks to the budget they receive from corporate. Two examples of past bonuses: free trail rides at an equestrian stadium and a barbeque with lassoing and horseshow throwing lessons.

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

8. 《疯狂的麦克斯4:狂暴之路》,导演:乔治·米勒。

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

制造业表现较好,利润增长6.5%。受低廉的能源价格的提振,电力、热力、燃气及水生产和供应业利润增长17%。

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
From the themed collection: 去年全国300城土地收入破4万亿
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

经济学人智库表示,尽管没有一个北美城市进入前20名,但是纽约的生活成本相对于其他美国城市有所上升。纽约与洛杉矶并列第27位成为美国最贵城市。
The .40-calibre Smith & Wesson that killed her, a semi-automatic handgun, was seized by police to undergo ballistics testing to determine if it had been used in other crimes.
6.Belize
Volatility in currency markets is also likely to be a factor for agricultural commodity prices in the next 12 months, with the euro likely to depreciate as a result of French, Dutch and German elections, Rabobank reckons.

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
From the themed collection: 文化价值引领实木家具消费热潮
Perspective

Trends and targets in antiviral phototherapy

“我去的每一个地方,都发现企业主对未来的需求量有一个很好的预期,” Gus Faucher PNC金融服务机构的资深经济学家称。“商人必须提高薪酬来吸引更多的劳动力或者保留原有的工人”。
这是伦敦商学院(London Business School)和哥伦比亚商学院(Columbia Business School)合办的EMBA-Global项目首次跌出前5名。
? Heavy snow has fallen in West Virginia, with up to 17 inches in Webster Springs. The National Weather Service has warned that more is on the way.
Promote steady development of agriculture and continued increases in rural incomes

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

"Everywhere I go business owners are seeing an increase in demand," said Gus Faucher, senior economist at PNC Financial Services. "Businesses will have to raise wages to attract or maintain workers."

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
From the themed collection: 家具电商为何屡中“电伤”
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

My hunch is that this draft will look pretty good by March and will be much better than last year's, which was one of the most underwhelming in recent memory. New Orleans and Washington both need some direction, and soon.

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

有些人则特地请人代劳:
上海独立IT专家李亦在接受《环球时报》采访时表示,智能手机数量激增是网民数量增长的主要原因。

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

Overall, starting a company ranked lowest among reasons cited for undertaking an EMBA (rated 5.5 out 10). Students’ main motivations were learning about management (9.1), networking (8.3) and increasing earnings (8.1).
尽管榜单上以法国和英国学校居多,占全部上榜学校的44%,但今年的排行榜比以往任何时候都更多元化,上榜学校来自25个国家。

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
From the themed collection: 北京二手房成交量连跌俩月
Open Access Review Article

Diagnostic technologies for COVID-19: a review

单词释义:
报告称,去年销售的手机大部分是预装安卓系统和支持4G的智能手机。

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

[m?s]
[tr?'din?l]
单词polish 联想记忆:
时报影评人曼诺拉·达吉斯(Manohla Dargis)与A·O·斯科特(A. O. Scott)分享他们挑选的年度最佳电影。

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

Men and women rated the strengths of their programme equally.

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

The Magic have bounced between average and bad, and they're currently on a downswing. Now Aaron Gordon and Nikola Vucevic are coming off the bench and Mario Hezonja is buried.
Siemens broke records last year by winning two awards for renaming its healthcare business Healthineers. Not only does it land the Martin Lukes prize for the worst combination of two words, the accompanying video, featuring a singing CEO and writhing spandex-clad employees, wins a gold medal for most embarrassing company song of all time.

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

1Switzerland

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

中欧之间存在贸易摩擦,我们有经验去妥善解决。

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

不过,如果把10月份看做一个整体,则只有深圳房价真正出现了环比下滑。
该报告指出,代理商和投资机构的涌入导致世界第二大经济体的增长方式和平台发生了额外的变化。小米科技公司的投资人和创始人雷军、360董事长周鸿祎、中国首富王健林等众多互联网大咖都大力支持流媒体的网络直播,这强烈表明了投资网红经济的巨大利润。
在全球前50名女富豪中,中国大陆的女企业家占56%。
The tightening drove some enterprises seek other financing options such as bonds or listing on the National Equities Exchange and Quotations (NEEQ).

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

我们只把精力在应该关注的地方
由美国演员Jared Leto领衔的“火星三十秒”拿到了最佳另类音乐奖,同时还有Lana Del Rey,Lorde,The XX和Imanine Dragons等人提名。
据国际足联秘书长杰罗姆·瓦尔克说,贝老爷子的1950年版门票将在苏黎世的一家博物馆展出,展览定于2015年开放。他还说:“这版球票很稀有,我们希望博物馆能够珍藏。”
Below are 10 clues you left that basically scream: "I am job searching!"
伦敦商学院(London Business School,见上图)荣登2014年英国《金融时报》欧洲商学院排行榜榜首,该学院上一次夺得冠军宝座是在2005年。法国巴黎高等商学院(HEC Paris)和西班牙企业商学院(IE Business School)分列二、三位。

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

美联储去年花了六个多月的时间暗示其有意退出第三轮购债计划,这种可能性时常扰动着市场。目前美联储仅处于退出购债计划的第一阶段。
The American share in the total drugspending is about one third. IMS experts estimate that in 2014 it will rise11.7 percent. The UShas particularly high prices, according to the report, but drug makers defendthis by citing the soaring cost of new medicine development.

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

《一记耳光》(The Slap),NBC,2月12日播出。乔恩·罗宾·贝茨(Jon Robin Baitz)与丽莎·查罗登科(Lisa Cholodenko)担任制作人,这部剧改编自一部澳大利亚迷你剧,讲述一个后院生日派对失控后带来的后果。演员阵容非常强大,包括彼得·萨斯加德(Peter Sarsgaard)、乌玛·瑟曼(Uma Thurman)、桑迪·牛顿(Thandie Newton)、布莱恩·考克斯(Brian Cox)和梅丽莎·乔治(Melissa George,她也在原剧中出演角色)。

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

有理由怀疑纳伦斯-诺埃尔是否能成长为可靠的先发中锋,这些理由包括他的伤病史、场外红灯行为和非常有限的进攻手段。

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

这台叫做IP-BOX的设备可以破解运行iOS 7或者更老版本的iPhone,通常它需要6秒到17小时来破解iPhone的四位锁屏密码。英国《每日邮报》购买了这台设备,并在6小时内破解了苹果iPhone 5c的锁屏密码。该密码破解设备运行在iOS 9系统上的版本将会在本月晚些时候出现。
“不能再采取某些国家先行动,其他国家随后行动的策略,因为时间不多了,”奥斯陆国际气候与环境研究中心(Center for International Climate and Environmental Research)的科学家格伦·P·彼得斯(Glen P. Peters)说。他也参与了这些新数据的编制。“现在需要大家齐心协力。”
整个夏天,每隔一周,Good Humor冰淇淋卡车在周五午餐时就会拜访这家公司。而在秋季,公司每个月有两个上午会给大家提供苹果酒和甜甜圈。
But a quick look at the changing skyline betrays a frustrating reality: Those shiny new towers have failed to deliver the type of housing most New Yorkers can afford. “There is a disconnect between what we’re building and what we need to build,” said Jonathan J. Miller, the president of the appraisal firm Miller Samuel. “2015 is going to be more of that.”

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

当银行打电话给哈维尔的父母,告诉他们有关收费的事情的时候,他们才知道发生了这样的事情。
The area is close to the city centre and the demolition contractors had to make sure that when they brought down the buildings they did not damage a light rail viaduct nearby or a shopping mall and electricity sub-station.
Warm hearted wishes for a happy New Year filled with all your favorite things.传统佳节之际,献上殷殷祝福,祝新年万事如意!
vt. 谣传

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

The findings of the US and UK scientists are based on thousands of global temperature measurements taken daily on land and at sea.
McGowan has also hit out at Meryl Streep, saying that it is 'literally impossible' the actress knew nothing of Weinstein's sexual proclivities until last autumn.

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

8. It’s never too late to start.
在过去的20年里,日本有些城市的生活成本达到过世界最高,但现在正在降低。东京和大阪分别降低了11名和14名。
7. Pumping Iron Could Enhance Long-Term Memory
"She gave her surname as Han when registering, which is also different from the name Su in media reports," the employee said.
金维刚补充说道:“去年前三季度职工平均工资增长幅度大致在6.3%,而我国2016年GDP增速则为6.7%。这两项都要比之前一年有所下降。”

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
From the themed collection: “京津冀家居产业园区”落户白沟
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

7.You Haven't Gotten a Raise in the Last Two Years
PBS的"越南战争"赢得美国电影学会颁发的特别奖。
“From one son of the South and sports fanatic to another, my hat’s off to you,” tweeted Bill Clinton, the former US president, in response to the article.

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

研究人员表示,去年之所以特别引人瞩目,是因为除了1月和4月以外,每个月都会创下新的全球高温记录,或与记录持平。
国家卫生健康委员会在上周五的一场新闻发布会上表示,2017年中国各高校共出现3077例新增艾滋病毒感染病例。

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

虽然引起了一定混乱,但维密秀的执行制作人艾德·拉泽克称赞中国合作方是“令人愉快又热情的东道主”。
The report didn't comment on potential factors influencing the numbers, but many – including members of the opposing political party – are laying the blame squarely at the feet of government cost-cutting.
n. 泄漏

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

在其他杯赛中,尽管没有做调查,但同样也呈现出类似趋势。
The school ranks first for alumni satisfaction.
"The online Internet anti-corruption bid mostly relies on text, photos and videos and it is easy to be superficial if corrupt officials are only exposed this way."

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
From the themed collection: 恒生指数报收28224.7点 内房股大跌
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

From the themed collection: 压减数千亿涉企收费举措细则将出
Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

流行天后嘎嘎小姐凭借她在HBO热门短剧《美国恐怖故事:旅馆》中扮演的反面角色获得了最佳女主角的奖杯。当她上台领奖时,她的情绪很激动。

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

setting

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

国务院总理李克强在上周五由人力资源和社会保障部组织的一次会议上表示,要优先促进就业。
Why? Just add in the intensifying anger after the Supreme Court's decisions over same-sex marriage issues and gays, add in the growing anger over abortions, Obamacare, gun control, food stamps, the new voter suppression pushed by GOP governors, plus more threats by conservatives and the tea party to dig in their heels and fight to overturn everything and increase austerity too.

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

accurate
Local-level work experience will advantageous for applicants, with personnel with more than two years of experience at this level given some advantage.
这是两部后自语核(post-mumblecore)喜剧,讲述自我认知及其边界的故事。布西内斯克的影片是完美的怪人三角,三条边分别是盖·皮尔斯(Guy Pearce)、寇碧·史莫德斯(Cobie Smulders)和凯文·科利根(Kevin Corrigan),以德克萨斯州奥斯汀怪人们轻松胡混的伪装出现。皮文的影片探索精神病以及日间电视节目的的黑暗疆域。由于克里斯汀·韦格(Kristen Wiig)的精彩演出(她饰演一个名叫爱丽丝·克里格的彩票得主),《欢迎来到我的世界》成了关于美国梦想者的精彩肖像,既令人不安,也鼓舞人心。
高通(Qualcomm)总部所在地的农民们肯定像它的雇员一样超爱这家无线电公司。每周,高通会在其总部圣地亚哥择址两处举办农夫市集。出售的商品从传统农产品到果酱、果冻无所不包。凡是订购了“社区支持农业”素食礼盒的高通雇员,在总部的一家咖啡馆即可轻松收货。

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

Social networking platforms, including Weibo and mobile app WeChat, proved to be the best tools for cyberstars to magnify the power of communication, making it possible to create an industry that combines advertisements, e-commerce and fans.
“如果你读了这本书,你就会发现,在这个故事里有个小插曲,我想那在某种程度上报复了邦德有些傲慢的态度。”

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

Rouslan Krechetnikov和Hans Mayer对液体的溅出现象进行了研究。他们考察的课题是:人们在端着咖啡杯走动时咖啡的溅出情况,给你个提示吧,在你走到第七步至第十步之间,咖啡最容易溅出。
天文学家在2016年宣布,LIGO阵列检测到了两个黑洞碰撞所释放出来的引力波,证实了爱因斯坦广义相对论的关键部分。研究人员因这项发现而获得了诺贝尔物理学奖。但是研究人员的发现仍未结束:10月,科学家们监测到了两颗中子星的碰撞,不仅听到了碰撞造成的时空涟漪,而且还用性能强大的望远镜在光学上确认了这一事件。中子星的碰撞被认为是宇宙中所有重金属的来源,包括黄金和白银,LIGO的探测有助于验证有关宇宙化学形成的解释。

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

安德森想让男人们脸上的毛发丰富多样,每个演员脸上装饰的胡子都不太一样。它是名符其实的时髦派风格,从一字胡、八字胡,再到杰夫·戈德布拉姆(Jeff Goldblum)的黑灰色山羊胡。

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

Until now Thor has been the neglected child of the Marvel Cinematic Universe. Though some liked Kenneth Branagh’s first film featuring the god of thunder, Chris Hemsworth was arguably overshadowed by Tom Hiddleston’s preening popinjay of a villain, Loki. And the second film, the humourless Thor: The Dark World, is widely regarded as the worst film released by Marvel Studios to date. So to inject new life into this sagging franchise, Marvel brought in New Zealand comedy auteur Taiki Waititi to add some Kiwi quirk. This time Thor faces down the goddess of death, played by Cate Blanchett. Thor may have the hammer, but she has the attitude. Released November 1 in Serbia and Hungary, November 2 in Cambodia and Israel and November 3 in India and Canada. (Credit: Marvel Studios)
The city of 21 million people recorded 1.86 trillion yuan in total consumption in 2015, marking a yearly rise of 8.7 percent. Consumption contributed over 70 percent to the city's GDP growth.
Madison Marriage is accounting and tax correspondent
200911/90348.shtml

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

Hope you enjoy the happiness of New Year and all the trimmings.
More than 430,000 students from 1,767 universities in 31 provinces, municipalities and autonomous regions across China were surveyed. Of the respondents, 89.2% had considered starting a business, with 18.2% reporting firm intentions to do so.

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

TextPride was a fine business, but a tiny one. Meanwhile, the market for messaging apps was exploding. Facebook FB 0.61% bought WhatsApp for $19 billion; that service now has 700 million monthly active users. Tango, an app with 250 million registered users, is worth $1.5 billion. Kik has 200 million registered users. Snapchat, worth $10 billion, has 100 million users. A new study, commissioned by Kik, shows that U.S. users now spend more time on average in messaging apps than they do on social networking apps. The only problem? These messaging apps need ways to make money, and there’s no reasonable way for advertisers to wedge themselves into conversations between friends.
9. Add Personality
10月份,日本工业产出环比增长1.4%,是自1月份出现4.1%的增幅以来增长最快的一次。这一数字高于9月份1.1%的增幅,不过仍低于经济学家1.8%的增长预期。

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

Global pharmaceutical spending will surpassthe trillion dollar threshold in 2014, with high prices for innovativehepatitis C and cancer drugs in the US, a new study says. By 2018spending is expected to increase by another 30 percent.
长久以来,科学家一直在研究干细胞分化为心脏组织的潜力,今年当他们创造出可以自己搏动的心脏组织时,这一研究工作达到了一个重要的里程碑。
According to the Hurun Report’s annual China Rich List, Yao Zhenhua’s net worth surged more than nine times to $17.2bn last year, making him the country’s fourth richest person. Last year he was ranked 204th.

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
From the themed collection: 房企销售数据虽“靓”或难撑股价
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

A 19-year-old girl, referred to as Guo Lingling (this may be a pseudonym), was allegedly struck and kicked repeatedly by her so-called instructors after failing to ask permission to go to the bathroom. An autopsy report showed she died from skull injuries and brain damage.
Best chances: A best film nomination looks certain. Darkest Hour's Gary Oldman is the favorite for best actor, but if anyone can beat him it's probably Chalamet.

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

n. 银河,一群显赫之人
['mu:vm?nt]
价格:197.5万元(约合人民币1264万元)

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
From the themed collection: “便利店+”时代正在来临
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

但是这位少年依然没有放弃,他还留了最后一手。
Lopez Short is the name of the game, judging from the red carpet looks of Beyoncé and Jennifer Lopez. Both divas went for thigh-high dresses to show off their gams4, with strategically cut out neck and shoulder detail, but where Beyoncé opted to stand out in fire engine red, J. Lo went for soft and satiny earth tones.

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

1.《刺客聂隐娘》(The Assassin)与《疯狂的麦克斯4:狂暴之路》(Mad Max: Fury Road),并列。侯孝贤和乔治·米勒(George Miller)导演了今年最好的两部商业片,二者都应该到你能找到的最大的屏幕上去看。
Staff numbers at insurance agencies also rose by 936,200 to a total of more than 5.6m people.
When you need help, reach out to people in your networks – that’s what they’re there for. Whether you need a confidence-boosting pep talk or advice about building your technical experience — your mentor, your colleagues, and your manager can help. You may not know how to do something today, but chances are you’re smart enough to find someone who can help you learn it. And once you do, don’t unfasten your seatbelt – there’s always going to be another challenge headed your way.

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

我们要求FlightAware对航班抵达延误情况进行统计,而不是航班出发延误情况,因为有时候,航空公司可以让飞机在空中飞行期间追回地面上失去的时间。

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

威廉凯特夫妇多次让加拿大人等候多时,例如,抵达加拿大时,两人花了20分钟时间才从飞机上下来接受加方欢迎团队的问候。
去年电影市场的一个亮点是,共有七部高质量的国产影片在票房前10名的榜单中。其中就包括真人与动画结合的《捉妖记》、以及基于经典古代故事的3D动画电影《大圣归来》。

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

我们不妨借用一些狄更斯的名句,来回顾下几乎各种战略都失灵的2014年:
祝老师新年充满平安和爱。

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
From the themed collection: 五项注意理性选购“学区房”
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

['elig?nt]
Jack Ma, founder and executive chairman of e-commerce giant Alibaba Group topped the ranking of China's richest IT people for the third consecutive year.

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

Among the 772 movies made in China in 2016, 43 of them reached a box office of over 100 million yuan. Chinese movies harvested an overseas box office of 3.8 billion yuan in 2016 with a yearly increase of over 38%.
2016年的政治动荡——英国退欧和唐纳德.特朗普(Donald Trump)当选美国总统——是民主的胜利还是对民主的威胁?民主政体必须对合法的抱怨做出回应。

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

But the economic picture has brightened considerably in Arizona, as the housing market stabilized and unemployment hit a post-recession low of 7.8% in May. As part of Forbes’ annual Best States for Business, we look at 35 factors to determine the best and worst states, including projected employment. Arizona is expected to have the fastest job growth at 3% annually over the next five years, according to Moody’s Analytics. The job gains are projected to boost household incomes 3.6% annually through 2017, which ranks second best in the U.S. after Illinois. The added jobs also go hand-in-hand with the state’s economic growth, which Moody’s forecasts to expand at a U.S.-best 4.6% annually.

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

储氦新发现
We learned that we could see a source of ripples in space-time.
Company: BlogHer
President Obama's Cabinet, of which Clinton was once a member, currently comprises seven women and 16 men.

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

动词limit的过

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

Among dozens of small, technology-focused acquisitions, the $3bn purchase of Beats Electronics, the celebrity-endorsed headphones and music streaming service, stands out as Apple’s largest ever deal. The acquisition still bemuses many Apple analysts, but in Jimmy Iovine and Dr Dre, Beats’ founders, Mr Cook has instantly regained credibility with the music industry after years of neglecting the iTunes download store. If Mr Cook is guilty of missing the rapid growth of subscription services such as Spotify, he has moved swiftly to compensate for it — though for a high price.
STONINGTON, CONN.
在西方国家更新、更广泛的国民身份认同里,白人们也有自己的一席之地。但是除非他们接受这一点,“白”的危机仍会持续存在下去。

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

Although the average punctuality rate of the surveyed airports rose 7% year-on-year to 70.4% in 2016, the average delay time was 33 minutes.
当科比的身体长到了6尺6寸时,高中时期的他已经是一个相当中型身板的家伙。可以想象,在1996年,想抵挡住17岁的科比进攻就很难。我相信,这几乎是不可能的。

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

A New York City restaurant is taking a stab at creating the most decadent pizza on the market with a pie topped in gold flakes, foie gras and even truffles.
原指拍film用的film(n 胶卷)-轻而薄且不牢固的

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
From the themed collection: 有了超材料 童话将变成现实
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

That figure is more than two times the city's population of about 10 million.

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

站在舞台中央,莱昂纳多发言说:“这是无上的荣誉,对我意义重大。两年前当我们置身于荒野当中拍摄电影,我们深深地被大自然的美丽和庞杂所感染。
35岁的阿德里亚娜·利马身着一件凸显身材的白色抹胸式礼服。这位巴西模特选择了简单又时髦的装扮,她把头发扎了起来,戴着一条抢眼的项链,项链上缀满了钻石。
译文属可可原创,仅供学习交流使用,未经许可请勿转载

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

com共同+plex重叠→全部重叠→复杂的
Sixty Vocab:
支持:影片可能会凭借出色的票房表现从缓慢变革的奥斯卡投票人群上获益。
[breis]

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

近几年,得益于世界日新月异,就像保护异性夫妻一样, LGBT群体(女同性恋、男同性恋、双性恋、跨性别人士)也会得到同样的权利保障。事实上,如今60%的美国人承认同性婚姻的合法性,如果你问那剩余的40%呢?我们可以告诉你美国的其他地方以及世界的其他地方,例如俄罗斯,很快都会赶上脚步。
[ei'li:t]

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

赫梅尔还指出,2008年油价飙升的局面(当时油价升破每桶140美元)将重现,但不太可能发生在2014年。他说,“油价将会上涨。”
英国《金融时报》EMBA项目排行榜在对商学院和2011年毕业生进行调查的基础上编制,可以让人们大致了解学员在读EMBA前后的变化。
Stand: Starbucks CEO Howard Schultz urged the end of government shutdown

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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几家与韩国有关系的机构已经感受到了北京方面对萨德计划的怒火。上个月,由于乐天(Lotte)出让土地用于部署萨德平台,中国官方新闻机构新华社(Xinhua)向乐天发出了强硬警告。乐天是韩国最大的企业之一。
201109/155435.shtmlIn August, Jose Javier - from the city of Torrevieja - created an account with AdWords, a Google pay-per-click service.

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